Volume-10, Issue-3, March 2024

Abstract

Borderline personality disorder (BPD) and alcohol abuse are both associated with impulsivity, while patients with trichotillomania demonstrate higher rates of co-morbid impulsive disorders. Impulsivity stems from overactive protein kinase C (PKC), and thus, targeting PKC can treat impulsivity. This case describes the effectiveness of endoxifen, a direct PKC inhibitor, in a patient with co-morbid BPD, alcohol dependence syndrome, and trichotillomania. There was reduced impulsivity and a motivation to cease alcohol consumption with endoxifen treatment. The patient transitioned from reluctance to disulfiram treatment to a willingness to take disulfiram. This case report adds valuable knowledge on the potential of endoxifen for patients with BPD and alcohol abuse.

Keywords: borderline personality disorder, endoxifen, protein kinase C, substance abuse, trichotillomania.

References

References not available